How to Apply

Please submit the following:

Your CV.

Contact information for three references.

A cover letter describing:

• Why joining the Xiao Lab would enhance your training.
• How your existing skills and training could contribute to the lab.
• Exciting research projects or future directions you would like to pursue.

We look forward to your application.

Job Summary

The Laboratory of Spatial Systems Biology, led by Dr. Yang Xiao in the Department of Pathology at the University of Michigan Medical School, invites applications for a Postdoctoral Research Fellow position. Our highly interdisciplinary lab focuses on investigating genetic and epigenetic changes in traumatic brain injury. The successful candidate will work on animal models of brain injuries and apply cutting-edge spatial multi-omic sequencing to study the cellular and molecular changes. The role involves both experimental and computational work under the supervision of the Principal Investigator.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world?s most distinguished academic health systems.  In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

• Excellent medical, dental and vision coverage effective on your very first day

Responsibilities*

• Collect and process tissue samples towards histopathology and spatial sequencing experiments.
• Extract RNA/ DNA from tissues and prepare sequencing libraries.
• Analyze spatial sequencing data using Python or R.
• Perform rodent neurosurgeries, such as craniotomy and cerebral microdialysis.
• Conduct rodent surgical injection techniques, including intracranial injections, intravenous injections, and oral gavage.
• Design, revise and maintain animal protocols.
• Perform photoacoustic imaging of the mouse brain.
• Maintain accurate and detailed records of experimental procedures and results.
• Collaborate with and assist other lab members on related projects.
• Follow and maintain laboratory protocols and procedures.

Required Qualifications*

• PhD degree in Biomedical Engineering, Pathology, Bioinformatics, Electrical Engineering or a related field.
• At least 5 years of research experience in biology or a related discipline.
• Publication record demonstrating computational skills in image processing or genomic data analysis.
• Proficiency in rodent neurosurgeries.
• Familiar with Linux OS, virtual environment working and batch scripting.
• Programming proficiency in R, Python, or MATLAB.

Desired Qualifications*

• Research experience in Molecular Biology, Digital Pathology, Epigenetics, Systems Biology, and Bioinformatics.
• Research experience of microfabrication, soft-lithography, and microfluidics.
• Knowledge of statistical methods commonly used in single-cell and spatial omics, such as Seurat and Scanpy.
• Experience with machine learning models, such as transformer and diffusion models.
• Strong written and oral communication skills.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO Statement

The University of Michigan is an equal employment opportunity employer.