How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Job Summary

The Fonseca Laboratory seeks a highly skilled Research Laboratory Specialist Lead to join an NIH-funded research program investigating how early-life respiratory viral infections alter lung development and drive long-term pulmonary disease. The position involves advanced molecular, cellular, and computational techniques using mouse and human systems.

The successful candidate will lead and support projects involving bulk and single-cell RNA sequencing (scRNA-seq), lung organoid development, confocal microscopy, in situ hybridization, and multi-omics analysis (ChIP-seq, ATAC-seq). The candidate will design and implement CRISPR/Cas9 genome-editing experiments, analyze complex datasets, and collaborate across multidisciplinary teams.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems.  In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?

• Excellent medical, dental and vision coverage effective on your very first day
• 2:1 Match on retirement savings

Responsibilities*

• Design and execute experiments involving bulk RNA-seq and scRNA-seq sample preparation, sequencing, and data analysis.
• Develop, culture, and analyze human and murine lung organoids; perform confocal imaging and in situ hybridization.
• Generate and analyze epigenetic datasets (ChIP-seq, ATAC-seq) and integrate multi-omics results.
• Design and perform CRISPR/Cas9 gene-editing and screening experiments.
• Manage data organization, documentation, and compliance with institutional standards.
• Contribute to manuscript preparation, grant reports, and supervision of trainees.

Required Qualifications*

• Ph.D., in Molecular Biology, Bioinformatics, or a related field, with 6+ years of experience.
• Proven expertise with bulk and single-cell RNA sequencing workflows and data analysis.
• Hands-on experience developing and imaging 3D organoid cultures (human and/or murine).
• Demonstrated proficiency in epigenomic assays (ChIP, Chip-seq, or related).
• Experience designing and implementing CRISPR/Cas9 experiments.
• Excellent written, analytical, and organizational skills.

Desired Qualifications*

• Background in cell development, stem cell biology.
• Proficiency with bioinformatics tools (R, Python, Seurat, Cell Ranger, or similar).
• Experience with murine models and human samples processing.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO Statement

The University of Michigan is an equal employment opportunity employer.