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Principal Scientist, Biomarker Data Sciences

San Francisco, CA
Full-Time

Job Description

About This Role:

As a Principal Scientist in Biomarker Data Sciences within the Clinical Biomarkers group at the West Coast Hub, you will lead the charge in multi-omics analyses of extensive clinical trial datasets, with a particular focus on NGS and proteomics. This role is pivotal in generating biological insights that will directly inform clinical development strategies. You will be advancing the understanding of CD38 immune cell-driven biology, collaborating closely with clinical teams, biostatistics, medical affairs, and key medical experts. Your ability to translate complex data into impactful insights will bring immense value to our business, ensuring our developments are both innovative and effective. With a seat at the heart of our operations, you will contribute strategically to our clinical biomarker initiatives, aligning closely with our overarching business goals.

What You'll Do:

* Lead and execute integrative multi-omics analyses from large clinical cohorts.

* Translate complex NGS and proteomics data into actionable biological and clinical insights.

* Partner closely with clinical teams, medical experts, biostatistics, and medical affairs to address critical clinical trial questions.

* Contribute to biomarker strategy, exploratory endpoints, and interpretation of clinical trial results.

* Communicate findings clearly and effectively to cross-functional, clinical, and scientific stakeholders.

Who You Are:

You are a highly collaborative individual with outstanding communication skills. Your ability to clearly translate complex data into impactful insights sets you apart. You thrive in cross-functional environments, where your expertise in bioinformatics and your passion for advancing clinical research drive you. Your approach is both analytical and creative, enabling you to contribute significantly to clinical biomarker strategies. Your enthusiasm for working with diverse teams and your commitment to excellence make you an invaluable asset to our organization.

Required Skills:

* PhD in Bioinformatics, Computational Biology, Immunology, or a related field.

* 5+ years of relevant industry experience.

* Hands-on experience analyzing NGS and/or proteomics data from large clinical datasets.

* Outstanding written and verbal communication skills and a demonstrated ability to work in highly collaborative, cross-functional environments.

Preferred Skills:

* Relevant postdoctoral training.

* Background in immunology and/or autoimmune disease biology.

* Experience supporting biomarker discovery and mechanism-of-action studies in clinical trials.


Job Level: Professional


Additional Information

The base compensation range for this role is: $141,000.00-$188,000.00


Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

  • Medical, Dental, Vision, & Life insurances
  • Fitness & Wellness programs including a fitness reimbursement
  • Short- and Long-Term Disability insurance
  • A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
  • Up to 12 company paid holidays + 3 paid days off for Personal Significance
  • 80 hours of sick time per calendar year
  • Paid Maternity and Parental Leave benefit
  • 401(k) program participation with company matched contributions
  • Employee stock purchase plan
  • Tuition reimbursement of up to $10,000 per calendar year
  • Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.Read onto learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

VEVRAA Federal Contractor.
We request Priority Protected Veteran & Disabled Referrals for all of our locations within the state.

PDN-a1e06afc-cea0-4523-9238-a83f3edca967

About This Role:

As a Principal Scientist in Biomarker Data Sciences within the Clinical Biomarkers group at the West Coast Hub, you will lead the charge in multi-omics analyses of extensive clinical trial datasets, with a particular focus on NGS and proteomics. This role is pivotal in generating biological insights that will directly inform clinical development strategies. You will be advancing the understanding of CD38 immune cell-driven biology, collaborating closely with clinical teams, biostatistics, medical affairs, and key medical experts. Your ability to translate complex data into impactful insights will bring immense value to our business, ensuring our developments are both innovative and effective. With a seat at the heart of our operations, you will contribute strategically to our clinical biomarker initiatives, aligning closely with our overarching business goals.

What You'll Do:

* Lead and execute integrative multi-omics analyses from large clinical cohorts.

* Translate complex NGS and proteomics data into actionable biological and clinical insights.

* Partner closely with clinical teams, medical experts, biostatistics, and medical affairs to address critical clinical trial questions.

* Contribute to biomarker strategy, exploratory endpoints, and interpretation of clinical trial results.

* Communicate findings clearly and effectively to cross-functional, clinical, and scientific stakeholders.

Who You Are:

You are a highly collaborative individual with outstanding communication skills. Your ability to clearly translate complex data into impactful insights sets you apart. You thrive in cross-functional environments, where your expertise in bioinformatics and your passion for advancing clinical research drive you. Your approach is both analytical and creative, enabling you to contribute significantly to clinical biomarker strategies. Your enthusiasm for working with diverse teams and your commitment to excellence make you an invaluable asset to our organization.

Required Skills:

* PhD in Bioinformatics, Computational Biology, Immunology, or a related field.

* 5+ years of relevant industry experience.

* Hands-on experience analyzing NGS and/or proteomics data from large clinical datasets.

* Outstanding written and verbal communication skills and a demonstrated ability to work in highly collaborative, cross-functional environments.

Preferred Skills:

* Relevant postdoctoral training.

* Background in immunology and/or autoimmune disease biology.

* Experience supporting biomarker discovery and mechanism-of-action studies in clinical trials.


Job Level: Professional


Additional Information

The base compensation range for this role is: $141,000.00-$188,000.00


Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

  • Medical, Dental, Vision, & Life insurances
  • Fitness & Wellness programs including a fitness reimbursement
  • Short- and Long-Term Disability insurance
  • A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
  • Up to 12 company paid holidays + 3 paid days off for Personal Significance
  • 80 hours of sick time per calendar year
  • Paid Maternity and Parental Leave benefit
  • 401(k) program participation with company matched contributions
  • Employee stock purchase plan
  • Tuition reimbursement of up to $10,000 per calendar year
  • Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.Read onto learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

VEVRAA Federal Contractor.
We request Priority Protected Veteran & Disabled Referrals for all of our locations within the state.

PDN-a1e06afc-cea0-4523-9238-a83f3edca967

About Biogen

Biogen Inc. is an American multinational biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurological diseases to patients worldwide.

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Biogen
Principal Scientist, Biomarker Data Sciences
Biogen
San Francisco, CA
May 27, 2026
Full-time
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