Job Description

We are seeking a collaborative, self-motivated Senior Scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) Group within the Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) organization at our Company's Research Laboratories in West Point, PA. The main goal of this position is to support the advancement of drug candidates through characterization of absorption, distribution, metabolism, and elimination (ADME) properties of therapeutics. Successful candidates will provide enzymology expertise and independently design and execute experiments utilizing in silico, in vitro, and in vivo methodologies to assess drug disposition and drugdrug interaction risk, and contribute to decisionmaking for lead discovery and development. The role requires strong laboratory execution, data analysis and documentation skills, the ability to work across interdisciplinary project teams, and the capacity to design novel approaches to solve complex mechanistic and analytical problems. Successful candidates will set high standards for scientific rigor and timely delivery of results while collaborating with colleagues to drive operational impact. This position offers an opportunity to grow professionally while contributing to the discovery and development of innovative medicines.

Education Minimum Requirement

• Bachelor's degree in analytical chemistry, biochemistry, pharmaceutical sciences, pharmacology, enzymology, bioengineering, toxicology, or a related scientific discipline with 7+ years relevant experience, Master's degree with 4+ years relevant experience, or Ph.D. with 0+ years relevant experience.

Required Experience and Skills

• Experience performing enzyme kinetics experiments and kinetic data analysis to address mechanistic questions that inform project decisionmaking.

• Handson experience with quantitative bioanalysis (LCMS/MS or equivalent) for drugs and biological molecules.

• Proficiency in data analysis and documentation tools (Excel, GraphPad Prism, electronic lab notebooks; familiarity with Spotfire or similar platforms preferred).

• Strong problem solving, attention to detail, autonomy, critical thinking, and growth mindset; demonstrated ability to prioritize, plan with ownership and accountability to deliver high quality results on time.

• Excellent interpersonal and communication skills; with a track record of collaborating effectively within crossfunctional teams and presenting results to project stakeholders.

Preferred Experience and Skills

• Proven ability to design, execute and interpret in vitro ADME/DMPK studies (e.g. metabolic stability, substrate phenotyping, inhibition, induction, protein binding) using tissues, cell systems, subcellular fractions, and recombinant enzymes.

• Experience supporting projects across multiple therapeutic areas and modalities (e.g. small molecules, peptides, biologics).

• Experience handling radiolabeled materials, tissue preparations, and biological matrices.

• Experience developing or implementing automation for in vitro ADME assays and leveraging informatics platforms for data collation/interpretation.

• Prior experience in a researchdriven pharmaceutical or biotech environment.

• Demonstrated mentoring experience with associate scientists.

• Understanding of regulatory guidance for in vitro DDI risk assessment and translating results to program teams.

• Familiarity with translational/in vivo study design or integration of in vitro-in vivo data to support pharmacokinetic and safety assessment.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R377285